Health trajectories of patients with amyotrophic lateral sclerosis before and after initiation of non-invasive ventilation: a French nationwide database analysis
Pneumologie
SNDS
article
Auteurs : Pierre Tankéré, Emilien Bernard, Eleonore Herquelot, Hélène Denis, Lilian Sfeir, Christel Saint-Raymond, Martial Mallaret, Florent Lavergne, Sébastien Baillieul, Laure Peter-Derex, Renaud Tamisier, Jean Louis Pépin
Date de publication : 30 janvier 2026
Objectifs
Management of amyotrophic lateral sclerosis (ALS) is complicated by heterogeneous presentation and unpredictable disease course. This study described disease trajectories before and after initiation of non-invasive ventilation (NIV) therapy in individuals with ALS, examined the relationship between NIV initiation timing and survival and analysed health trajectory clusters.
Conclusion
There was marked heterogeneity between patients with ALS and their care trajectories. Our data do not support a universal benefit for early initiation of NIV therapy.