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Heva, filiale de Docaposte et une expertise de La Poste Sant\u00e9 & Autonomie, est un acteur majeur de la valorisation des donn\u00e9es de sant\u00e9 : de la collecte, \u00e0 l\u2019exploitation et la restitution des r\u00e9sultats.<\/p>\n
Elle accompagne les professionnels de l\u2019industrie pharmaceutique, du dispositif m\u00e9dical, les entreprises de biotechnologie ou encore et les institutionnels du secteur de la sant\u00e9 dans la gestion de tous types d\u2019\u00e9tudes sur donn\u00e9es de sant\u00e9.<\/p>\n
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Ing\u00e9nieur(e) \u2013 D\u00e9ploiement d’une strat\u00e9gie IA agentique en environnement CRO | <\/strong>6 mois | Lyon | \u00c0 partir de septembre 2026 <\/strong>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1″ custom_padding_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb module_class=\u00a0\u00bbparallax\u00a0\u00bb _builder_version=\u00a0\u00bb4.24.2″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_color=\u00a0\u00bbgcid-f237d54e-6be2-4a68-9ae3-f3ddd196256e\u00a0\u00bb background_image=\u00a0\u00bbhttps:\/\/heva-data.com\/wp-content\/uploads\/2025\/04\/technology-software-programming-develop-idea-peopl-2025-03-15-04-27-40-utc-1.jpg\u00a0\u00bb background_blend=\u00a0\u00bbhard-light\u00a0\u00bb module_alignment=\u00a0\u00bbcenter\u00a0\u00bb min_height=\u00a0\u00bb750px\u00a0\u00bb custom_padding=\u00a0\u00bb||0px||false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb||0px||false|false\u00a0\u00bb 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width_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb max_width=\u00a0\u00bb90%\u00a0\u00bb custom_margin=\u00a0\u00bb6vw||6vw||false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb\u00a0\u00bb custom_padding_phone=\u00a0\u00bb0px||||false|false\u00a0\u00bb custom_css_free_form=\u00a0\u00bbselector{|| z-index:500;||}\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb1_2″ _builder_version=\u00a0\u00bb4.24.2″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb custom_padding=\u00a0\u00bb50px|50px|50px|50px|false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb50px|50px|50px|50px|false|false\u00a0\u00bb custom_padding_phone=\u00a0\u00bb30px|10px|30px|10px|false|false\u00a0\u00bb custom_padding_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_css_free_form=\u00a0\u00bbselector{|| position: relative;|| z-index: 1; \/* S’assurer que le texte est au-dessus *\/|| background-color: rgba(221, 242, 242, 0.95); \/* Turquoise tram\u00e9 \u00e0 15% *\/|| opacity: 1; \/* Effet de transparence \u00e0 95% *\/|| color: #000; \/* Couleur du texte, \u00e0 ajuster si n\u00e9cessaire *\/|| backdrop-filter: blur(5px);|| -webkit-backdrop-filter: blur(5px);||}\u00a0\u00bb border_radii=\u00a0\u00bbon|30px|30px|30px|30px\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_text_color=\u00a0\u00bbgcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2″ text_font_size=\u00a0\u00bb16px\u00a0\u00bb custom_padding=\u00a0\u00bb|26px||0px|false|false\u00a0\u00bb locked=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{%22gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2%22:%91%22text_text_color%22%93}\u00a0\u00bb]<\/p>\n Titre :<\/strong> D\u00e9ploiement d’une strat\u00e9gie IA agentique en environnement CRO<\/p>\n Dur\u00e9e :<\/strong> 6 mois | Lieu :<\/strong> Lyon, France | D\u00e9marrage :<\/strong> \u00e0 partir de septembre 2026<\/p>\n Qui sommes-nous ?<\/strong><\/p>\n HEVA est un CRO (Contract Research Organization) sp\u00e9cialis\u00e9 dans les \u00e9tudes en vie r\u00e9elle (Real-World Evidence) et l’\u00e9valuation m\u00e9dico-\u00e9conomique. Nous accompagnons les industriels de la sant\u00e9 dans la g\u00e9n\u00e9ration de preuves \u00e0 partir de donn\u00e9es m\u00e9dico-administratives fran\u00e7aises (SNDS, PMSI) et internationales, sur un spectre large d’aires th\u00e9rapeutiques.<\/p>\n <\/p>\n Nos \u00e9quipes r\u00e9unissent Chefs de projets, ARCs, pharmaco\u00e9pid\u00e9miologistes, data managers, biostatisticiens, data scientists, designers et d\u00e9veloppeurs.<\/p>\n <\/p>\n Le contexte du stage<\/strong><\/p>\n HEVA engage une transformation structurelle de ses pratiques gr\u00e2ce \u00e0 l’IA agentique. Nous avons d\u00e9j\u00e0 d\u00e9ploy\u00e9 un premier actif et nous souhaitons franchir l’\u00e9tape suivante : d\u00e9ployer des agents IA d\u00e9di\u00e9s \u00e0 chaque m\u00e9tier, int\u00e9gr\u00e9s \u00e0 nos outils et gouvern\u00e9s par un cadre de s\u00e9curit\u00e9 adapt\u00e9 aux contraintes des donn\u00e9es de sant\u00e9.<\/p>\n <\/p>\n Ce stage s’inscrit au c\u0153ur de ce projet. Il couvre \u00e0 la fois la dimension technique \u2014 configuration et d\u00e9ploiement des agents, construction des bases de connaissance, d\u00e9veloppement des connecteurs \u2014 et la dimension organisationnelle \u2014 adoption par les \u00e9quipes, formation, suivi des usages.<\/p>\n <\/p>\n En compl\u00e9ment des agents no-code\/low-code, certains cas d\u2019usage pourront n\u00e9cessiter un d\u00e9veloppement sp\u00e9cifique lorsqu\u2019ils ne sont pas r\u00e9alisables directement via la plateforme agentique retenue. Le ou la stagiaire pourra ainsi contribuer \u00e0 la conception et au d\u00e9veloppement d\u2019un outil ou prototype cod\u00e9 sur l\u2019un de ces cas d\u2019usage identifi\u00e9s, en lien avec les \u00e9quipes m\u00e9tier, data science et d\u00e9veloppement web.<\/p>\n <\/p>\n <\/p>\n Vos missions<\/strong><\/p>\n En lien direct avec les \u00e9quipes m\u00e9tier, vous aurez la responsabilit\u00e9 de :<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_2″ _builder_version=\u00a0\u00bb4.24.2″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb custom_padding=\u00a0\u00bb50px|50px|50px|50px|false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb50px|50px|50px|50px|false|false\u00a0\u00bb custom_padding_phone=\u00a0\u00bb30px|10px|30px|10px|false|false\u00a0\u00bb custom_padding_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb custom_css_free_form=\u00a0\u00bbselector{|| position: relative;|| z-index: 1; \/* S’assurer que le texte est au-dessus *\/|| background-color: rgba(221, 242, 242, 0.95); \/* Turquoise tram\u00e9 \u00e0 15% *\/|| opacity: 1; \/* Effet de transparence \u00e0 95% *\/|| color: #000; \/* Couleur du texte, \u00e0 ajuster si n\u00e9cessaire *\/|| backdrop-filter: blur(5px);|| -webkit-backdrop-filter: blur(5px);||}\u00a0\u00bb border_radii=\u00a0\u00bbon|30px|30px|30px|30px\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_text_color=\u00a0\u00bbgcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2″ text_font_size=\u00a0\u00bb16px\u00a0\u00bb custom_padding=\u00a0\u00bb|26px||0px|false|false\u00a0\u00bb locked=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{%22gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2%22:%91%22text_text_color%22%93}\u00a0\u00bb]<\/p>\n <\/p>\n <\/p>\n Profil recherch\u00e9<\/strong><\/p>\n Vous \u00eates \u00e9tudiant(e) en derni\u00e8re ann\u00e9e d’une formation de niveau Bac+5 dans l’un des domaines suivants :\u00a0<\/p>\n <\/p>\n Comp\u00e9tences appr\u00e9ci\u00e9es<\/strong><\/p>\n Un plus appr\u00e9ci\u00e9 : toute familiarit\u00e9 avec le secteur de la sant\u00e9, des donn\u00e9es m\u00e9dico-administratives ou des probl\u00e9matiques de donn\u00e9es sensibles.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb4.24.2″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb background_enable_color=\u00a0\u00bboff\u00a0\u00bb background_image=\u00a0\u00bbhttps:\/\/heva-data.com\/wp-content\/uploads\/2025\/03\/line_green3_left.png\u00a0\u00bb background_size=\u00a0\u00bbcustom\u00a0\u00bb background_image_height=\u00a0\u00bb600px\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_vertical_offset=\u00a0\u00bb0%\u00a0\u00bb custom_margin=\u00a0\u00bb-390px|0px|0px||false|false\u00a0\u00bb custom_padding=\u00a0\u00bb|0px|0px|0px|false|false\u00a0\u00bb custom_css_free_form=\u00a0\u00bbselector{|| width:740px;|| height:390px;|| top:auto;bottom:-120px;|| left:auto;right:-15px;|| z-index:0;||}\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.24.2″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00a0\u00bb1″ _builder_version=\u00a0\u00bb4.24.2″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_row _builder_version=\u00a0\u00bb4.24.2″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″ _builder_version=\u00a0\u00bb4.24.2″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.27.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb text_text_color=\u00a0\u00bbgcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2″ text_font_size=\u00a0\u00bb16px\u00a0\u00bb link_text_color=\u00a0\u00bbgcid-4aeecbf4-ad8a-42cd-966b-141db4843095″ custom_padding=\u00a0\u00bb|26px||0px|false|false\u00a0\u00bb locked=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{%22gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2%22:%91%22text_text_color%22%93,%22gcid-4aeecbf4-ad8a-42cd-966b-141db4843095%22:%91%22link_text_color%22%93}\u00a0\u00bb]Ce que nous offrons<\/strong><\/p>\n Localisation<\/strong>\u00a0: Lyon, avec possibilit\u00e9 de t\u00e9l\u00e9travail partiel.<\/p>\n Gratification<\/strong>\u00a0: selon profil et r\u00e9glementation en vigueur.<\/p>\n <\/p>\n Processus de candidature<\/strong><\/p>\n Envoyez CV + lettre de motivation \u00e0 benjamin.grenier@heva-data.com<\/a>, daniel.podevin@heva-data.com<\/a>, et nicolas.reynaud@heva-data.com<\/a> en indiquant en objet : Stage IA Agentique \u2013 [votre pr\u00e9nom nom].[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Heva, filiale de Docaposte et une expertise de La Poste Sant\u00e9 & Autonomie, est un acteur majeur de la valorisation des donn\u00e9es de sant\u00e9 : de la collecte, \u00e0 l\u2019exploitation et la restitution des r\u00e9sultats. Elle accompagne les professionnels de l\u2019industrie pharmaceutique, du dispositif m\u00e9dical, les entreprises de biotechnologie ou encore et les institutionnels du […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[et_pb_section fb_built=\"1\" _builder_version=\"4.24.2\" _module_preset=\"default\" background_enable_image=\"off\" custom_margin=\"||0px||false|false\" custom_padding=\"0px||||false|false\" locked=\"off\" global_colors_info=\"{}\"][et_pb_row column_structure=\"3_5,2_5\" make_equal=\"on\" custom_padding_last_edited=\"on|phone\" _builder_version=\"4.24.2\" _module_preset=\"default\" width_tablet=\"\" width_phone=\"90%\" width_last_edited=\"on|phone\" custom_margin_tablet=\"\" custom_margin_phone=\"||0px||false|false\" custom_margin_last_edited=\"on|phone\" custom_padding_tablet=\"\" custom_padding_phone=\"||0px||false|false\" global_colors_info=\"{}\"][et_pb_column type=\"3_5\" _builder_version=\"4.24.2\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.27.4\" _module_preset=\"default\" text_text_color=\"gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2\" text_font_size=\"16px\" header_text_align=\"center\" module_alignment=\"center\" custom_padding=\"|0px||0px|false|true\" locked=\"off\" global_colors_info=\"{%22gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2%22:%91%22text_text_color%22,%22text_text_color%22,%22text_text_color%22,%22text_text_color%22,%22text_text_color%22,%22text_text_color%22,%22text_text_color%22%93}\"] Heva, filiale de Docaposte et une expertise de La Poste Sant\u00e9 & Autonomie, est un acteur majeur de la valorisation des donn\u00e9es de sant\u00e9 : de la collecte, \u00e0 l\u2019exploitation et la restitution des r\u00e9sultats.<\/p>\n Elle accompagne les professionnels de l\u2019industrie pharmaceutique, du dispositif m\u00e9dical, les entreprises de biotechnologie ou encore et les institutionnels du secteur de la sant\u00e9 dans la gestion de tous types d\u2019\u00e9tudes sur donn\u00e9es de sant\u00e9.<\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"2_5\" _builder_version=\"4.24.2\" _module_preset=\"default\" background_color=\"gcid-c0e66333-91cf-44de-bb84-3ca29293711d\" background_enable_color=\"off\" background_image=\"https:\/\/heva-data.com\/wp-content\/uploads\/2025\/03\/people-working-in-co-working-office-2025-03-09-17-18-57-utc-1.jpg\" custom_padding=\"10%||||false|false\" custom_padding_tablet=\"10%||||false|false\" custom_padding_phone=\"30%||||false|false\" custom_padding_last_edited=\"on|phone\" custom_css_free_form=\"selector{|| border:3px solid white;||}\" border_radii=\"on|30px|30px|30px|30px\" global_colors_info=\"{%22gcid-c0e66333-91cf-44de-bb84-3ca29293711d%22:%91%22background_color%22%93,%22gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2%22:%91%22background_color%22%93}\"][\/et_pb_column][\/et_pb_row][et_pb_row use_custom_gutter=\"on\" gutter_width=\"2\" make_equal=\"on\" _builder_version=\"4.24.2\" _module_preset=\"default\" custom_margin=\"25px||25px||true|false\" custom_padding=\"20px|20px|20px|20px|true|true\" custom_css_free_form=\"selector{|| z-index:500;|| position: relative;|| z-index: 1; \/* S'assurer que le texte est au-dessus *\/|| background-color: rgba(221, 242, 242, 0.95); \/* Turquoise tram\u00e9 \u00e0 15% *\/|| opacity:1; \/* Effet de transparence \u00e0 95% *\/|| color: #000; \/* Couleur du texte, \u00e0 ajuster si n\u00e9cessaire *\/|| backdrop-filter: blur(5px);|| \/* Pr\u00e9fixe pour la compatibilit\u00e9 avec Safari *\/|| -webkit-backdrop-filter: blur(5px);||}\" border_radii=\"on|30px|30px|30px|30px\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.24.2\" _module_preset=\"default\" custom_padding=\"20px|10px|10px|10px|false|true\" border_radii=\"on|20px|20px|20px|20px\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.27.4\" _module_preset=\"default\" text_text_color=\"gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2\" text_font_size=\"16px\" header_text_align=\"center\" text_orientation=\"center\" module_alignment=\"center\" custom_padding=\"|0px||0px|false|true\" locked=\"off\" global_colors_info=\"{%22gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2%22:%91%22text_text_color%22,%22text_text_color%22,%22text_text_color%22,%22text_text_color%22,%22text_text_color%22,%22text_text_color%22,%22text_text_color%22%93}\"]Nous cherchons :[\/et_pb_text][et_pb_text _builder_version=\"4.27.4\" _module_preset=\"default\" text_text_color=\"gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2\" text_font_size=\"24px\" header_2_font=\"|700|||||||\" header_2_text_align=\"center\" header_2_text_color=\"gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2\" header_2_font_size=\"33px\" header_3_font=\"|700|||||||\" header_3_text_align=\"center\" header_3_text_color=\"gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2\" header_3_font_size=\"24px\" text_orientation=\"center\" custom_margin=\"0px||0px||false|false\" custom_padding=\"0px|0px|0px|0px|false|true\" custom_css_free_form=\"selector span{|| color:#1aa6a6;||}\" locked=\"off\" global_colors_info=\"{%22gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2%22:%91%22text_text_color%22,%22header_2_text_color%22,%22header_3_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22header_3_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22header_3_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22header_3_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22header_3_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22header_3_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22header_3_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22header_3_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22header_3_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22header_3_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22header_3_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22header_3_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22header_3_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22header_3_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22header_3_text_color%22,%22text_text_color%22,%22header_2_text_color%22,%22header_3_text_color%22%93}\"]STAGE M2 (F\/H) \u2013 M\u00e9thodologie Pharmaco\u00e9pid\u00e9miologique & Real-World Evidence \u2013 Lyon<\/strong>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" custom_padding_last_edited=\"on|phone\" module_class=\"parallax\" _builder_version=\"4.24.2\" _module_preset=\"default\" background_color=\"gcid-f237d54e-6be2-4a68-9ae3-f3ddd196256e\" background_image=\"https:\/\/heva-data.com\/wp-content\/uploads\/2025\/04\/technology-software-programming-develop-idea-peopl-2025-03-15-04-27-40-utc-1.jpg\" background_blend=\"hard-light\" module_alignment=\"center\" min_height=\"750px\" custom_padding=\"||0px||false|false\" custom_padding_tablet=\"||0px||false|false\" custom_padding_phone=\"0px||0px||false|false\" custom_css_free_form=\"selector{|| overflow:hidden;|| width:calc(100% - 140px);|| left:70px;||} ||\/* Adaptation pour les \u00e9crans plus petits (mobile) *\/||@media screen and (max-width: 768px) {|| selector {|| width: calc(90%); \/* R\u00e9duction de la marge pour s'adapter aux petits \u00e9crans *\/|| left: 5%; \/* Ajustement du d\u00e9calage lat\u00e9ral *\/|| }||}\" border_radii=\"on|20px|20px|20px|20px\" locked=\"off\" global_colors_info=\"{%22gcid-f237d54e-6be2-4a68-9ae3-f3ddd196256e%22:%91%22background_color%22%93}\"][et_pb_row column_structure=\"1_2,1_2\" make_equal=\"on\" custom_padding_last_edited=\"on|phone\" _builder_version=\"4.24.2\" _module_preset=\"default\" width_tablet=\"\" width_phone=\"90%\" width_last_edited=\"on|phone\" max_width=\"90%\" custom_margin=\"6vw||6vw||false|false\" custom_padding_tablet=\"\" custom_padding_phone=\"0px||||false|false\" custom_css_free_form=\"selector{|| z-index:500;||}\" global_colors_info=\"{}\"][et_pb_column type=\"1_2\" _builder_version=\"4.24.2\" _module_preset=\"default\" custom_padding=\"50px|50px|50px|50px|false|false\" custom_padding_tablet=\"50px|50px|50px|50px|false|false\" custom_padding_phone=\"30px|10px|30px|10px|false|false\" custom_padding_last_edited=\"on|phone\" custom_css_free_form=\"selector{|| position: relative;|| z-index: 1; \/* S'assurer que le texte est au-dessus *\/|| background-color: rgba(221, 242, 242, 0.95); \/* Turquoise tram\u00e9 \u00e0 15% *\/|| opacity: 1; \/* Effet de transparence \u00e0 95% *\/|| color: #000; \/* Couleur du texte, \u00e0 ajuster si n\u00e9cessaire *\/|| backdrop-filter: blur(5px);|| -webkit-backdrop-filter: blur(5px);||}\" border_radii=\"on|30px|30px|30px|30px\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.27.4\" _module_preset=\"default\" text_text_color=\"gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2\" text_font_size=\"16px\" custom_padding=\"|26px||0px|false|false\" locked=\"off\" global_colors_info=\"{%22gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2%22:%91%22text_text_color%22%93}\"] Titre :<\/strong> Robustesse des \u00e9tudes comparatives en vie r\u00e9elle : cartographie des t\u00e9moins n\u00e9gatifs (Negative Control Outcomes<\/em>) et calibration empirique dans le SNDS<\/p>\n Dur\u00e9e :<\/strong> 6 mois | Lieu :<\/strong> Lyon, France | D\u00e9marrage :<\/strong> Janvier 2027<\/p>\n Les \u00e9tudes observationnelles d'efficacit\u00e9 et de s\u00e9curit\u00e9 comparatives constituent aujourd'hui le socle de la production de preuves en vie r\u00e9elle (Real-World Evidence<\/em>, RWE), qu'il s'agisse de d\u00e9cisions de remboursement, d'\u00e9valuations post-inscription ou d'\u00e9tudes de pharmacovigilance active. Malgr\u00e9 le recours \u00e0 des m\u00e9thodes d'ajustement avanc\u00e9es \u2014 scores de propension, pond\u00e9ration par l'inverse de la probabilit\u00e9 de traitement (IPTW), appariement \u2014 un biais r\u00e9siduel syst\u00e9matique persiste dans la quasi-totalit\u00e9 des \u00e9tudes observationnelles, en raison notamment des facteurs de confusion non mesur\u00e9s : biais d'indication, healthy user bias<\/em>, fragilit\u00e9 non cod\u00e9e dans les bases m\u00e9dico-administratives.<\/p>\n L'approche par calibration empirique (Empirical Calibration<\/em>), formalis\u00e9e et popularis\u00e9e par le consortium OHDSI dans le cadre du programme LEGEND, propose une r\u00e9ponse quantitative \u00e0 ce d\u00e9fi. Le principe consiste \u00e0 estimer la distribution empirique du biais r\u00e9siduel en mesurant l'effet apparent du traitement sur une s\u00e9rie d'\u00e9v\u00e9nements t\u00e9moins n\u00e9gatifs (Negative Control Outcomes<\/em>, NCOs) \u2014 des \u00e9v\u00e9nements cliniques pour lesquels toute relation causale avec le traitement est biologiquement non plausible. Si un signal appara\u00eet sur ces t\u00e9moins, il refl\u00e8te n\u00e9cessairement un biais syst\u00e9matique que l'on peut mod\u00e9liser et corriger. Cette distribution de l'hypoth\u00e8se nulle empirique est ensuite utilis\u00e9e pour recalibrer l'estimateur et les intervalles de confiance de l'outcome d'int\u00e9r\u00eat.<\/p>\n Bien que la m\u00e9thode soit d\u00e9sormais reconnue comme une bonne pratique m\u00e9thodologique dans les grandes \u00e9tudes de pharmaco\u00e9pid\u00e9miologie internationale, son d\u00e9ploiement en routine sur des donn\u00e9es fran\u00e7aises reste tr\u00e8s limit\u00e9. La principale raison tient \u00e0 l'absence de cartographie structur\u00e9e des NCOs adapt\u00e9s aux sp\u00e9cificit\u00e9s du Syst\u00e8me National des Donn\u00e9es de Sant\u00e9 (SNDS) \u2014 codage CIM-10, CCAM, remboursements DCIR \u2014 et aux diff\u00e9rentes aires th\u00e9rapeutiques.<\/p>\n Le stage s'articule autour de deux axes compl\u00e9mentaires.<\/p>\n Axe m\u00e9thodologique<\/strong> :<\/p>\n Axe appliqu\u00e9<\/strong> :<\/p>\n Mettre en \u0153uvre une preuve de concept (proof of concept<\/em>) compl\u00e8te de calibration empirique sur un cas d'usage r\u00e9el \u00e0 partir du SNDS, en allant de la construction de cohorte jusqu'\u00e0 la recalibration de l'estimateur principal.<\/p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"4.24.2\" _module_preset=\"default\" custom_padding=\"50px|50px|50px|50px|false|false\" custom_padding_tablet=\"50px|50px|50px|50px|false|false\" custom_padding_phone=\"30px|10px|30px|10px|false|false\" custom_padding_last_edited=\"on|phone\" custom_css_free_form=\"selector{|| position: relative;|| z-index: 1; \/* S'assurer que le texte est au-dessus *\/|| background-color: rgba(221, 242, 242, 0.95); \/* Turquoise tram\u00e9 \u00e0 15% *\/|| opacity: 1; \/* Effet de transparence \u00e0 95% *\/|| color: #000; \/* Couleur du texte, \u00e0 ajuster si n\u00e9cessaire *\/|| backdrop-filter: blur(5px);|| -webkit-backdrop-filter: blur(5px);||}\" border_radii=\"on|30px|30px|30px|30px\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.27.4\" _module_preset=\"default\" text_text_color=\"gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2\" text_font_size=\"16px\" custom_padding=\"|26px||0px|false|false\" locked=\"off\" global_colors_info=\"{%22gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2%22:%91%22text_text_color%22%93}\"] Phase 1 \u2014 Revue et cartographie des NCOs (mois 1\u20132)<\/strong><\/p>\n Le stagiaire conduira une revue structur\u00e9e de la litt\u00e9rature portant sur les pratiques de s\u00e9lection des NCOs dans les publications pharmaco\u00e9pid\u00e9miologiques majeures, en distinguant les approches de manual curation<\/em> (s\u00e9lection experte a priori) et les approches data-driven<\/em> (extraction algorithmique \u00e0 partir d'ontologies m\u00e9dicales ou de bases de pharmacovigilance).<\/p>\n Le livrable principal de cette phase est une matrice NCOs \u00d7 domaines th\u00e9rapeutiques, incluant pour chaque candidat NCO : le niveau de preuve de l'absence d'effet biologique, la faisabilit\u00e9 de codage dans le SNDS (codes CIM-10 \/ CCAM identifi\u00e9s), la sensibilit\u00e9 attendue dans les donn\u00e9es de remboursement, et les limites potentielles (sous-codage, variabilit\u00e9 inter-\u00e9tablissements). Ce document est con\u00e7u pour \u00eatre r\u00e9utilisable dans les futurs protocoles d'\u00e9tude et opposable aux autorit\u00e9s d'\u00e9valuation (HAS, EMA).<\/p>\n Phase 2 \u2014 Design du cas d'usage et extraction de donn\u00e9es (mois 3)<\/strong><\/p>\n Un cas d'usage sera d\u00e9fini en concertation avec l'\u00e9quipe encadrante, en s'appuyant sur des \u00e9tudes r\u00e9centes du bureau d\u2019\u00e9tude en cours ou achev\u00e9es pour lesquelles une r\u00e9analyse m\u00e9thodologique apporte une plus-value scientifique. La question de recherche sera formalis\u00e9e en format PICO et le protocole d'\u00e9tude adapt\u00e9 aux contraintes de l'ESND\/SNDS (effectifs, dur\u00e9e de suivi disponible, couverture des variables d'ajustement). La cohorte sera d\u00e9j\u00e0 construite \u00e0 partir des tables DCIR et PMSI MCO. Il sera n\u00e9cessaire d\u2019ajouter les variables n\u00e9cessaires \u00e0 l\u2019analyse propos\u00e9e dans le stage.<\/p>\n Phase 3 \u2014 Analyse statistique et calibration (mois 4\u20135)<\/strong><\/p>\n Les facteurs de confusion mesur\u00e9s seront ajust\u00e9s par des m\u00e9thodes \u00e0 base de score de propension. L\u2019outcome principal ainsi que le panel de NCOs s\u00e9lectionn\u00e9s en Phase 1 seront estim\u00e9s \u00e0 l\u2019aide mod\u00e8les de r\u00e9gressions adapt\u00e9s, afin de mod\u00e9liser la distribution empirique de l'hypoth\u00e8se nulle et de recalibrer les estimateurs de l'\u00e9tude.<\/p>\n Phase 4 \u2014 Synth\u00e8se et valorisation (mois 6)<\/strong><\/p>\n Le stagiaire r\u00e9digera son m\u00e9moire (structure IMRaD) et produira un script R \/ python document\u00e9, couvrant l'ensemble de la cha\u00eene analytique, destin\u00e9 \u00e0 \u00eatre int\u00e9gr\u00e9 aux workflows standard du bureau. Un abstract\/poster sera pr\u00e9par\u00e9 en vue d'une soumission \u00e0 un congr\u00e8s de pharmaco\u00e9pid\u00e9miologie (ISPE, DSVR ou EMOIS selon le calendrier).<\/p>\n Le stage s'adresse \u00e0 un(e) \u00e9tudiant(e) en deuxi\u00e8me ann\u00e9e de Master en Biostatistiques, \u00c9pid\u00e9miologie ou Sant\u00e9 Publique, avec une app\u00e9tence marqu\u00e9e pour les questions de validit\u00e9 interne et d'inf\u00e9rence causale en \u00e9tudes observationnelles.<\/p>\n Une exp\u00e9rience avec les bases de donn\u00e9es de sant\u00e9 fran\u00e7aises (SNDS\/EGB\/ESND) et une bonne ma\u00eetrise de SAS \/ R \/ Python constitue un atout significatif. La capacit\u00e9 \u00e0 lire et synth\u00e9tiser la litt\u00e9rature m\u00e9thodologique en anglais est attendue.<\/p>\n Au-del\u00e0 des comp\u00e9tences techniques, le profil recherch\u00e9 est celui d'un esprit rigoureux et critique, capable de questionner ses propres r\u00e9sultats et d'identifier les sources potentielles d'art\u00e9fact avant d'en tirer des conclusions. Une certaine autonomie de recherche est attendue d\u00e8s la Phase 1, tout en s'inscrivant dans un fonctionnement d'\u00e9quipe.<\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.24.2\" _module_preset=\"default\" background_enable_color=\"off\" background_image=\"https:\/\/heva-data.com\/wp-content\/uploads\/2025\/03\/line_green3_left.png\" background_size=\"custom\" background_image_height=\"600px\" background_position=\"top_left\" background_vertical_offset=\"0%\" custom_margin=\"-390px|0px|0px||false|false\" custom_padding=\"|0px|0px|0px|false|false\" custom_css_free_form=\"selector{|| width:740px;|| height:390px;|| top:auto;bottom:-120px;|| left:auto;right:-15px;|| z-index:0;||}\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.24.2\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.24.2\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.24.2\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.24.2\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.27.4\" _module_preset=\"default\" text_text_color=\"gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2\" text_font_size=\"16px\" link_text_color=\"gcid-4aeecbf4-ad8a-42cd-966b-141db4843095\" custom_padding=\"|26px||0px|false|false\" locked=\"off\" global_colors_info=\"{%22gcid-07fd6007-ae25-4e13-bbf0-52acc155a8b2%22:%91%22text_text_color%22%93,%22gcid-4aeecbf4-ad8a-42cd-966b-141db4843095%22:%91%22link_text_color%22%93}\"] Vos conditions de travail :<\/strong><\/p>\n Le stagiaire sera int\u00e9gr\u00e9 \u00e0 l'\u00e9quipe d'\u00e9pid\u00e9miologie et b\u00e9n\u00e9ficiera d'un encadrement direct par un pharmaco\u00e9pid\u00e9miologiste (Benjamin GRENIER). Les analyses s'effectueront sur un environnement s\u00e9curis\u00e9 conforme aux exigences du RGPD et aux r\u00e9f\u00e9rentiels de s\u00e9curit\u00e9 de la CNIL (donn\u00e9es pseudonymis\u00e9es). La gratification est conforme \u00e0 la r\u00e9glementation en vigueur.<\/p>\n<\/ol>\n
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